Table 2.
The systemic lupus erythematosus‐associated mRNA expressions identified by Mendelian randomization analysis
| Gene | CHR | SMR analysis | eQTL study | DEG | |||
|---|---|---|---|---|---|---|---|
| β | SE | P SMR | P HEIDI | ||||
| GLS | 2 | 0·8039 | 0·1657 | 1·23E‐06 | 0·18 | Westra | Yes |
| ZSCAN16 | 6 | 1·6606 | 0·2708 | 8·71E‐10 | 0·91 | CAGE | Yes |
| GABBR1 | 6 | 1·1092 | 0·2226 | 6·26E‐07 | 0·90 | GTEx | Yes |
| RPP21 | 6 | −3·2586 | 0·6150 | 1·17E‐07 | 0·05 | CAGE | Yes |
| HCP5 | 6 | −2·6344 | 0·4136 | 1·90E‐10 | 0·38 | CAGE | Yes |
| C6orf48 | 6 | 2·0189 | 0·3789 | 9·88E‐08 | 0·73 | GTEx | Yes |
| NEU1 | 6 | −3·4882 | 0·6370 | 4·36E‐08 | 0·95 | CAGE | Yes |
| NELFE | 6 | 0·7827 | 0·1594 | 9·05E‐07 | 0·06 | CAGE | No |
| SKIV2L | 6 | −0·6047 | 0·0887 | 9·49E‐12 | 0·12 | GTEx | No |
| C4A | 6 | −0·9127 | 0·1106 | 1·54E‐16 | 0·07 | GTEx | Yes |
| C4B | 6 | 0·8036 | 0·0962 | 6·64E‐17 | 0·13 | GTEx | Yes |
| CYP21A2 | 6 | 1·2416 | 0·2254 | 3·61E‐08 | 0·67 | GTEx | No |
| RNF5 | 6 | 1·9483 | 0·2168 | 2·56E‐19 | 0·07 | CAGE | Yes |
| C8ORF13 | 8 | 0·4747 | 0·0520 | 7·50E‐20 | 0·23 | Westra | No |
| FAM167A | 8 | 0·3658 | 0·0481 | 2·84E‐14 | 0·21 | CAGE | Yes |
| FAM167A | 8 | 0·3369 | 0·0521 | 1·01E‐10 | 0·41 | GTEx | Yes |
| BLK | 8 | −0·9493 | 0·1602 | 3·13E‐09 | 0·35 | GTEx | Yes |
| BLK | 8 | −0·5048 | 0·0625 | 6·88E‐16 | 0·11 | Westra | Yes |
| BLK | 8 | −0·3890 | 0·0515 | 4·35E‐14 | 0·33 | CAGE | Yes |
| ANO9 | 11 | −0·7016 | 0·1274 | 3·62E‐08 | 0·07 | CAGE | No |
| IRF7 | 11 | 0·4601 | 0·0846 | 5·33E‐08 | 0·81 | CAGE | Yes |
| DRD4 | 11 | 1·0887 | 0·2296 | 2·12E‐06 | 0·12 | Westra | No |
| ACAP1 | 17 | −0·3421 | 0·0610 | 2·06E‐08 | 0·32 | CAGE | Yes |
| ACAP1 | 17 | −0·3222 | 0·0557 | 7·07E‐09 | 0·10 | Westra | Yes |
| UBE2L3 | 22 | 1·3527 | 0·2462 | 3·93E‐08 | 0·06 | GTEx | Yes |
| UBE2L3 | 22 | 0·2671 | 0·0326 | 2·62E‐16 | 0·08 | CAGE | Yes |
CHR, chromosome; DEG, differentially expressed genes; eQTL, expression quantitative trait locus; HEIDI, heterogeneity in dependent instruments; SMR, summary data‐based Mendelian randomization.