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. 2020 Feb 4;8:39. doi: 10.3389/fbioe.2020.00039

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Copyright © 2020 Lee, Chun, Park, Kim, Whang, Choi, Baik, Park and Lee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune responses against pneumococcal polysaccharides in mice measured by OPA. (A) Before the process optimization. (B) After the process optimization. Prevenar 13^® was used as a comparator vaccine and PCV15 indicates the polysaccharide-carrier protein conjugate produced in this study by Eubiologics. (^∗p < 0.05, ^∗∗p < 0.01).