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. 2019 Apr 25;9(6):5268–5278. doi: 10.1021/acscatal.9b00918

Table 2. Screening of Chiral Ligands in the Asymmetric C−H Arylation of Complex 1a with 2a.

2.1.

Entry Ligand Yield 3aa (%)a er3aab Yield 4aa (%)a
1 (S)-L1 42 18:82 31
2 (S)-L2 40 32:68 26
3 (S)-L3 45 25:75 28
4 (R,R)-L4 39 51:49 29
5 (S)-L5 46 46:54 34
6 (S)-L6c 0 – 0
7 (S,Sp)-L7c 0 – 0
8 (S)-L8 40 16:84 31
9 (S)-L9 47 14:86 25
a

Determined by 1H NMR spectroscopy using 1,3,5-trimethoxybenzene as internal standard.

b

Determined by HPLC (Chiralpak IB hexane/isopropyl alcohol).

c

Reactions carried out with 10 mol % of ligand.