Table 4. H/D Exchange Experiments of 1ea.
Entry | Conditions | d1-1e (%)a |
---|---|---|
1 | Standard conditions without Ag2CO3 | 0 |
2 | 0.65 equiv Ag2CO3 | 0 |
3 | 0.65 equiv Ag2CO3, 5.5 mol % (R)-L10 | 0 |
4 | 0.65 equiv Ag2CO3, 5.5 mol % (R)-L10, 0.5 equiv Cy2CHCO2H | 0 |
5 | 0.65 equiv Ag2CO3, 2 equiv TMP | 32 |
6 | 0.65 equiv Ag2CO3, 5.5 mol % (R)-L10, 2 equiv TMP | 54 |
7 | 0.65 equiv Ag2CO3, 5.5 mol % (R)-L10, 0.5 equiv Cy2CHCO2H, 2 equiv TMP | 48 |
Determined by 1H NMR spectroscopy using 1,3,5-trimethoxybenzene as internal standard.