Table 3.
Analgesic activity (µM/kg), ulcerogenic index and cyclooxygenase inhibition (%).
| Mean number of writhes ± SEM |
Cyclooxygenase inhibition (%) |
||||||
|---|---|---|---|---|---|---|---|
| Compd. no. | 0.5 h | 1 h | 2 h | Ulcer index | COX-1 (%) | COX-2 (%) | S I |
| 17a | 260 ± 1.6 | 172 ± 2.1 | 153 ± 1.8 | – | – | – | – |
| 17b | 172 ± 3.5 | 421 ± 4.2 | 245 ± 4.6 | – | – | – | – |
| 17c | 96 ± 1.8 | 102 ± 1.2 | 89 ± 2.3 | 0.82 | 3.50 ± 0.81 | 89.20 ± 0.68 | 25.49 |
| 17d | 304 ± 1.2 | 275 ± 6.5 | 201 ± 2.3 | – | – | – | – |
| 17e | 167 ± 0.9 | 183 ± 1.8 | 174 ± 2.1 | – | – | – | – |
| 17f | 203 ± 3.2 | 189 ± 2.9 | 192 ± 2.3 | – | – | – | – |
| 17g | 127 ± 0.9 | 84 ± 1.2 | 76 ± 6.8 | – | – | – | – |
| 17h | 210 ± 1.3 | 187 ± 2.2 | 129 ± 6.3 | – | – | – | – |
| 17i | 84 ± 4.3 | 72 ± 5.3 | 69 ± 7.2 | 0.89 | 2.60 ± 0.72 | 78.50 ± 0.90 | 30.19 |
| 17j | 166 ± 2.9 | 182 ± 3.2 | 178 ± 2.3 | – | – | – | – |
| 17k | 108 ± 1.1 | 97 ± 1.2 | 80 ± 8.2 | – | – | – | – |
| 17l | 182 ± 2.2 | 195 ± 1.5 | 186 ± 3.6 | – | – | – | – |
| Celecoxib29 | 156 ± 4.8 | 72 ± 1.2 | 70 ± 3.9 | 0.92 | 2.20 ± 0.89 | 61.10 ± 0.88 | 27.77 |