Table 1.

Composition of VP-loaded polymeric beads adopting D-optimal design with their resultant dependent variables.

System Number	A: Polymer Type	B: Eudragit RS100 content (% w/w)a	C: Drug load (mg)	EE %± SD (% w/w)	Q 3hr ± SD (% w/w)	Q 6hr ± SD (% w/w)	Q 12hr ± SD (%w/w)
S1	PLGA 5004	0.00	109.40	98.02 ± 0.40	21.68 ± 11.40	31.72 ± 15.24	42.58 ± 15.10
S2		0.00	109.40	98.95 ± 0.14	17.50 ± 07.66	25.59 ± 09.60	37.53 ± 12.36
S3		10.41	40.00	93.41 ± 0.13	04.78 ± 01.11	04.79 ± 03.73	11.35 ± 02.62
S4		12.50	97.66	97.61 ± 0.03	20.18 ± 09.47	29.72 ± 12.76	40.27 ± 15.52
S5		14.57	160.00	98.11 ± 0.38	36.50 ± 12.04	49.36 ± 13.82	60.80 ± 12.13
S6		14.57	160.00	97.16 ± 0.42	46.64 ± 12.75	59.94 ± 15.11	73.07 ± 16.42
S7		21.88	40.00	92.94 ± 1.85	19.70 ± 03.84	19.27 ± 01.20	28.11 ± 00.56
S8		25.00	90.53	92.31 ± 1.79	42.15 ± 10.87	52.46 ± 10.09	64.72 ± 07.38
S9	PLGA 5010	0.00	40.00	96.68 ± 0.34	00.65 ± 00.58	02.73 ± 01.11	05.46 ± 05.59
S10		0.00	160.00	99.19 ± 0.03	32.14 ± 17.12	47.04 ± 21.13	65.35 ± 19.67
S11		0.00	160.00	99.30 ± 0.38	29.16 ± 05.70	44.27 ± 07.21	58.37 ± 05.89
S12		12.50	66.43	98.15 ± 0.40	06.65 ± 02.04	13.08 ± 03.55	21.98 ± 05.12
S13		12.50	130.10	98.88 ± 0.06	23.35 ± 00.52	35.93 ± 05.94	54.66 ± 09.53
S14		25.00	40.00	96.36 ± 0.32	22.35 ± 05.88	17.03 ± 02.26	27.39 ± 00.00
S15		25.00	160.00	97.29 ± 0.98	36.53 ± 05.86	55.62 ± 06.59	74.79 ± 05.97
S16	PCL	0.00	40.00	96.59 ± 0.31	39.25 ± 00.69	46.62 ± 00.73	61.08 ± 05.22
S17		0.00	40.00	96.30 ± 1.87	34.20 ± 00.39	37.56 ± 07.38	53.82 ± 08.97
S18		0.00	160.00	98.35 ± 0.06	52.79 ± 00.36	65.50 ± 00.80	75.36 ± 01.26
S19		0.00	160.00	98.94 ± 0.34	50.08 ± 04.94	61.01 ± 06.45	73.69 ± 06.89
S20		12.50	100.00	97.82 ± 0.64	47.79 ± 02.14	60.67 ± 01.68	69.65 ± 02.02
S21		23.05	59.82	97.50 ± 0.67	50.32 ± 05.24	59.42 ± 03.73	71.37 ± 03.54
S22		25.00	160.00	98.86 ± 0.08	72.69 ± 03.06	86.94 ± 05.99	95.90 ± 02.58

^aPercent out of total polymer weight (150 mg).