Table 2.

Univariable and multivariable Cox proportional hazard models for predicting cardiac events

	Univariable HR (95% CI)	P value	Multivariable HR (95% CI)	P value
Age (per 1 y increase)a	1.022 (1.007‐1.037)	.003	1.019 (1.002‐1.035)	.026
Male	0.938 (0.654‐1.346)	.729
Ischemic etiology	1.078 (0.685‐1.694)	.746
NYHA class III/IV	5.444 (2.521‐11.755)	<.001	5.950 (2.516‐14.068)	<.001
LVEF (per 1% increase)a	0.981 (0.970‐0.992)	.001	0.989 (0.977‐1.002)	.095
Holter monitoring
Average heart rate (per 1 beat increase)a	0.997 (0.985‐1.009)	.590
Atrial fibrillation	1.519 (1.054‐2.191)	.025	1.622 (1.083‐2.429)	.019
PVC burden (per 1% increase)a	1.046 (1.021‐1.071)	<.001	1.036 (1.005‐1.068)	.021
Hypertension	1.466 (0.888‐2.420)	.134
Diabetes	1.609 (1.132‐2.286)	.008	1.454 (0.993‐2.127)	.054
Dyslipidemia	1.060 (0.692‐1.624)	.788
Chronic kidney disease	2.435 (1.657‐3.578)	<.001	1.632 (1.051‐2.535)	.029
Anemia	2.230 (1.538‐3.233)	<.001	1.881 (1.243‐2.847)	.003
Device therapy
Pace maker	1.346 (0.497‐3.647)	.559
ICD/CRT‐P/CRT‐D	3.007 (1.722‐5.248)	<.001	1.408 (0.749‐2.650)	.288
Medication
β‐blockers	1.700 (0.938‐3.083)	.080
ACE inhibitors/ARBs	1.537 (0.909‐2.598)	.109
Amiodarone	2.844 (1.976‐4.094)	<.001	3.064 (2.004‐4.683)	<.001
Digitalis	1.416 (0.913‐2.196)	.121

Abbreviations: CI, confidence interval; HR, hazard ratio. The other abbreviations are as in Table 1.

^aContinuous variables.