Table 4. Comparison of Immunohistochemical Indicators Between Metformin and Control Groups.
| Immunohistochemical indicators | Metformin group | Control group | χ2 | P |
|---|---|---|---|---|
| EGFR | ||||
| Negative | 13 (39.4%) | 17 (30.4%) | 0.759 | 0.384 |
| Positive | 20 (60.6%) | 39 (69.6%) | ||
| E-cadherin | ||||
| Negative | 11 (33.3%) | 30 (53.6%) | 3.423 | 0.064 |
| Positive | 22 (66.7%) | 26 (46.4%) | ||
| N-cadherin | ||||
| Negative | 28 (84.8%) | 43 (76.8%) | 0.837 | 0.360 |
| Positive | 5 (15.2%) | 13 (23.2%) | ||
| MMP-2 | ||||
| Negative | 23 (69.7%) | 24 (42.9%) | 6.002 | 0.014* |
| Positive | 10 (30.3%) | 32 (57.1%) |
EGFR: epidermal growth factor receptor; MMP-2: matrix metalloproteinase-2. *P < 0.05.