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The conventional IP drug delivery. (A–D) The pathophysiology of tumor yields interstitial hypertension and opposing interstitial flow on the tumor surface as a result of the large interstitial pressure gradients near the tumor boundary, (E–F) The final intratumoral concentration of cisplatin is 1.75-folds greater than that of paclitaxel. Almost the same ratio holds between the AUC of these two cytotoxic agents, (G–I) Both paclitaxel and cisplatin show very limited penetration depths.
