Table. 1.
Model parameter values.
| Parameter | Significance | Unit | Value | Ref. |
|---|---|---|---|---|
| l | Magnet length | cm | 20 | (Nacev et al., 2012) |
| w | Magnet width | cm | 10 | (Nacev et al., 2012) |
| d | Tumor-magnet distance | cm | 5–20 | – |
| R | Tumor radius | mm | 1–10 | (Steuperaert et al., 2017) |
| K | Hydraulic conductivity of the interstitium | m2 Pa-1 sec-1 | 3.0×10-14 | (Baxter & Jain, 1989) |
| LP | Hydraulic conductivity of the microvascular | m Pa-1 sec-1 | 21×10-12 | (Sefidgar et al., 2014) |
| S/V | Vasculature surface area per unit volume | m−1 | 2×104 | (Soltani & Chen, 2011) |
| PB | Vascular pressure | Pa | 2.1×103 | (Soltani & Chen, 2011) |
| σ | Average osmotic reflection coefficient for plasma proteins | – | 0.82 | (Baxter & Jain, 1989) |
| πB | Microvessel osmotic pressure | Pa | 2.7×103 | (Baxter & Jain, 1990) |
| πi | Interstitial osmotic pressure | Pa | 2.0×103 | (Baxter & Jain, 1990) |
| χ | Magnetic susceptibility of magnetic particles | – | 20 | (Nacev et al., 2011a) |
| Brem | Remnant magnetic flux | T | 0.5–2.5 | (Ganguly et al., 2005; Nacev et al., 2011b) |
| af | Radius of the tumor matrix fibers | nm | 200 | (Nacev, 2013) |
| ϕ | Volume fraction of tumor matrix fibers | – | 0.66 | (Levick, 1987) |
| rp | Pore radius of tumor vessels | nm | 200 | (Stylianopoulos & Jain, 2013) |
| δ | Vessel wall thickness | µm | 5 | (Stylianopoulos et al., 2013) |
| β | Drug elimination constant | s−1 | 7.32×10-4 | (Steuperaert et al., 2017) |
| IC50 | Half maximal inhibitory concentration | mol m−3 | 1.4×10-6 (Paclitaxel) 6.2×10-3 (Cisplatin) |
(Steuperaert et al., 2017) |