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. 2016 Sep 22;55(1):96–100. doi: 10.1080/13880209.2016.1230140

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© 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/Licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Modified Schild plot for noncompetitive antagonism effect, according to the equation pA₂′ = pB_x′ + Log (X-1), where pB_x′ is the negative logarithm of the concentration (-Log B′) of antagonist (AMEO) and X is the ratio between maximal effect (E_max) of (A) carbachol or (B) histamine in the absence of antagonist (AMEO) and that in the presence of antagonist (AMEO on guinea-pig tracheal tissue. The pA₂′ value is the abscissa to the origin of the graph Log (X-1) vs pB_x′, when X = 2. Each point represents mean ± S.E.M. of at least six experiments.