Table 2.

Inhibitory concentration 50% (IC₅₀) of anti-proliferative activity of the tested compounds 3b-e, 5b-e, 7a, 7b, 10a-k, and Sunitinib toward HT-29, ZR-75, and A-549 cell lines.

	IC50 (µM)a
Compound No.	A-549	ZR-75	HT-29	Average IC50 (µM)
3b	11.25 ± 1.45	9.72 ± 2.52	21.05 ± 1.86	14.01
4c	6.07 ± 0.90	4.20 ± 0.57	8.49 ± 1.01	6.25
4d	26.09 ± 4.47	NAb	NAb	>28.69
3e	NAb	23.33 ± 0.0	NAb	>27.77
5b	4.87 ± 0.49	2.09 ± 0.12	6.15 ± 0.51	4.37
5c	2.15 ± 0.23	1.16 ± 0.39	4.29 ± 0.25	2.53
5d	12.53 ± 1.73	12.68 ± 2.40	15.32 ± 1.93	13.51
5e	3.54 ± 0.42	2.93 ± 0.46	8.51	7.49
7a	22.94 ± 3.51	NAb	NAb	>27.65
7b	2.29 ± 0.21	1.37 ± 0.23	2.75 ± 0.31	2.14
10a	9.41 ± 1.29	4.35	19.44 ± 1.03	11.07
10b	NAb	24.59	NAb	>28.19
10c	17.2 ± 2.56	4.89	NAb	>17.36
10e	4.79 ± 0.45	1.95 ± 1.03	7.25 ± 0.83	4.66
10f	22.72 ± 3.71	23.41	NAb	>25.38
10g	6.07 ± 7.41	1.87 ± 0.26	NAb	>12.65
10i	6.13 ± 0.76	1.96 ± 0.85	8.26 ± 0.86	5.45
10j	12.84 ± 1.40	10.91 ± 2.81	15.22 ± 1.10	12.99
10k	20.13 ± 3.81	3.61	19.75 ± 1.63	14.49
Sunitinib	10.14 ± 0.8	8.31 ± 2.4	5.87 ± 0.3	8.11

^aIC₅₀ values are the mean ± SD of four separate experiments.

^bNA: Compounds having IC₅₀ value >30 μM.