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Selectivity for compounds 7b, 10e, and Sunitinib towards tumor and non-tumorigenic cell lines.
| IC50 (µM) ± SD |
|||||
|---|---|---|---|---|---|
| Compound No. | Intestine IEC-6 | Breast MCF-10A | Fibroblast Swiss-3t3 | NSCLC A-549 |
Mean tumor selectivity |
| 7b | 8.70 ± 4.32 | 3.42 ± 0.45 | 6.85 ± 0.76 | 3.84 ± 0.67 | 1.6 |
| 10e | 8.98 ± 1.25 | 5.37 ± 0.61 | 8.51 ± 1.01 | 4.13 ± 0.61 | 1.8 |
| Sunitinib | 4.56 ± 0.54 | 4.43 ± 0.23 | 4.07 ± 0.75 | 3.06 ± 0.9 | 1.4 |
