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. 2019 Sep 12;4(1):pkz067. doi: 10.1093/jncics/pkz067

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© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Enrichment of immune system related pathways with low DNA Repair score using gene set enrichment analysis (GSEA). Genes ranked by the RNAseq2 analysis according to their correlation to the DNA Repair score were analyzed by GSEA to identify pathways (using gene ontology terms) that statistically significantly correlate with the DNA Repair score. The analysis was performed separately for case patients and control individuals. This leads to a list of pathways ranked according to their normalized enrichment score, the top 30 of which are shown in Supplementary Table 2 (available online). The figure presents for each tissue and health state all of the 366 immune system–related pathways as found by the GSEA analysis (according to keywords presented in Supplementary Table 2, available online). Each dot represents a pathway, with its y-axis value showing the false discovery rate, -Log(Q-value), for the enrichment score. The pathways are colored according to their false discovery rate values: gray dots Q-Value > 0.001, red dots Q-Value ≤ 0.001. Negatively and positively enriched pathways are shown for nasal and bronchial tissues, in case patients and control individuals, as indicated.