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Frequency of eight targetable genomic alterations across age groups.
The frequencies of EGFR kinase mutations(a), ALK rearrangements (b), ROS1 rearrangements (c) and RET arrangements (d) gradually decrease with age. The frequencies of BRAF-V600E, MET, ERBB2 and KRAS across age groups are, respectively, shown in E, F, G and H. Notably, an increasing trend toward older age at diagnosis was observed for MET and KRAS. Statistical significance was defined as P < .05.
