Table 1.
Mixed effects regression estimates (B) and post-hoc predicted means (M) of peripheral inflammatory markers by IBUD (vs. placebo) after METH infusion
| sICAM-1 (ng) | sVCAM-1 (ng) | cathepsin D (ng) | IL-6 (pg) | TNF-α (pg) | MIF (ng) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Regression estimates | B (95% CI) | p | B (95% CI) | p | B (95% CI) | p | B (95% CI) | p | B (95% CI) | p | B (95% CI) | p |
| IBUD | 0.16 (−13.30, 13.63) |
0.981 | −40.36 (−108.09, 27.37) |
0.243 | −5.86 (−31.62, 19.89) |
0.655 | 5.25 (0.61, 9.89) |
0.027 | 11.55 (−12.93, 36.03) |
0.355 | 2.08 (−0.18, 4.35) |
0.071 |
| Time | ||||||||||||
| 60 min. | 17.80 (6.49, 29.11) |
0.002 | 93.70 (13.06, 174.34) |
0.023 | 27.93 (7.19, 48.66) |
0.008 | 6.07 (−1.75, 13.89) |
0.128 | −8.89 (−32.78 14.99) |
0.466 | 0.08 (−0.25, 0.42) |
0.626 |
| 360 min. | 3.09 (−15.43, 21.61) |
0.744 | 41.56 (−61.25, 144.37) |
0.428 | 4.89 (−17.62, 27.40) |
0.670 | 24.50 (3.24, 45.75) |
0.024 | 41.76 (−41.75, 125.27) |
0.327 | 0.93 (−0.31, 2.17) |
0.143 |
| IBUD x time | ||||||||||||
| 60 min. | −17.29 (−34.50, −0.07) |
0.049 | −113.21 (−224.00, −2.42) |
0.045 | −30.32 (−60.36, −0.29) |
0.048 | −6.08 (−13.69, 1.54) |
0.118 | 11.79 (−15.13, 38.70) |
0.391 | −1.93 (−4.11, 0.25) |
0.082 |
| 360 min. | −10.04 (−24.77, 4.70) |
0.182 | −55.94 (−163.53, 51.65) |
0.308 | −7.38 (−43.15, 28.39) |
0.686 | −16.39 (−34.53, 1.76) |
0.077 | −17.50 | 0.383 | −1.38 (−4.68, 1.93) |
0.414 |
| (−56.83, 21.83) | ||||||||||||
| Sequence | 18.15 (−18.61, 54.91) |
0.333 | −8.76 (−207.11, 189.59) |
0.931 | 50.24 (−24.62, 125.10) |
0.188 | 4.36 (−10.67, 19.39) |
0.144 | 53.94 (−49.10, 156.98) |
0.305 | 0.18 (−1.35, 1.71) |
0.820 |
| Predicted means | M (95% CI) | p† | M (95% CI) | p† | M (95% CI) | p† | M (95% CI) | p† | M (95% CI) | p† | M (95% CI) | p† |
| Placebo | ||||||||||||
| 0 min. | 116.39 (90.47, 142.30) |
614.50 (498.84, 730.15) |
163.91 (122.74, 205.07) |
6.94 (4.06, 9.81) |
28.23 (−0.44 56.90) |
0.57 (0.18, 0.97) |
||||||
| 60 min. | 134.19 (110.38, 157.99) |
0.002 | 708.19 (564.11, 852.27) |
0.023 | 191.83 (138.08, 245.59) |
0.008 | 13.00 (6.26, 19.75) |
0.128 | 19.34 (2.46, 36.22) |
0.466 | 0.66 (0.37, 0.94) |
0.626 |
| 360 min. | 119.47 (103.64, 135.31) |
0.076 | 656.06 (538.02, 774.09) |
0.193 | 168.79 (131.06, 206.53) |
0.069 | 31.43 (8.15, 54.72) |
0.106 | 69.99 (−38.43, 178.41) |
0.354 | 1.50 (0.30, 2.70) |
0.105 |
| IBUD | ||||||||||||
| 0 min. | 116.55 (93.07, 140.03) |
574.14 (471.13, 677.15) |
158.04 (117.19, 198.90) |
12.18 (5.35, 19.02) |
39.78 (−11.09, 90.65) |
2.66 (0.44, 4.87) |
||||||
| 60 min. | 117.06 (95.38, 138.74) |
0.911 | 554.63 (446.04, 663.22) |
0.420 | 155.65 (110.92, 200.37) |
0.828 | 12.18 (5.71, 18.65) |
0.997 | 42.67 (−10.99, 96.33) |
0.218 | 0.81 (0.30, 1.32) |
0.069 |
| 360 min. | 109.60 (90.92, 128.28) |
0.169 | 559.76 (453.48, 666.03) |
0.873 | 155.55 (116.79, 194.31) |
0.987 | 20.29 (5.52, 35.06) |
0.152 | 64.04 (−29.79, 157.87) |
0.310 | 2.21 (0.93, 3.49) |
0.066 |
†
p-value corresponds to change in the predicted mean since the prior time point (e.g., 360 min. compared to 60 min.)