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. 2019 Nov 12;21(3):231–240. doi: 10.1080/15384047.2019.1683331

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Figure 6. — MiR-421 promotes the growth and migration of osteosarcoma cells by targeting MCPIP1 (a) Cells were divided into three groups and transfected with control, miR-421 and miR-421 with MCPIP1 respectively. The proliferation of MG63 cells was detected by MTT assay. Data are shown as mean ± SEM. ** P < .05 control vs miR-421, ##P < .05 miR-421 vs miR-421+ MCPIP1 (b) The migration of MG63 cells was detected by transwell assay. Cells were counted and results represent the mean±SD for three experiments. ** P < .05 control vs miR-421, ## P < .05 miR-421 vs miR-421+ MCPIP1 (c, d) The levels of MCPIP1, Cyclin D1, bcl-2, MMP2 and IL-6 in MG63 cells were detected by western blot and real-time PCR. Data are shown as mean ± SEM. ** P < .05 control vs miR-421, ## P < .05 miR-421 vs miR-421+ MCPIP1.