Table 4.

Unadjusted and Adjusted Odds Rations from Logistic Regression Models for Each of the Criteria for the Mediation Analysis in Singletons, Massachusetts Birth July 1, 2004–December 31, 2010

Criteria for Mediation	Unadjusted ORa (95% CI)	P-value	Adjusted ORb (95% CI)	P-value
ART. vs. Fertile (N= 404,604)
1. Relationship between ART and ASD	1.20 (1.00, 1.45)	0.05	1.08 (0.89, 1.31)	0.43
2. Relationship between ART and preterm	1.80 (1.69, 1.93)	<0.0001	1.51 (1.40, 1.63)	<0.0001
3. Relationship between preterm and ASD	1.57 (1.41, 1.75)	<0.0001	1.31 (1.17, 1.47)	<0.0001
Subfertile vs. Fertile (N=402,511)
1. Relationship between Subfertile and ASD	1.13 (0.91, 1.40)	0.26	1.11 (0.89, 1.39)	0.40
2. Relationship between Subfertile and preterm	1.28 (1.17, 1.39	<0.0001	1.17 (1.06, 1.28)	<0.01
3. Relationship between preterm and ASD	1.61 (1.44, 1.79)	<0.0001	1.34 (1.20, 1.50)	<0.0001
ICSI vs. Fertile (N=398,564)
1. Relationship between ICSI and ASD	1.26 (0.94, 1.68)	0.12	1.13 (0.85, 1.53)	0.29
2. Relationship between ICSI and preterm	1.75 (1.57, 1.95)	<0.0001	1.42 (1.27, 1.60)	<0.0001
3. Relationship between preterm and ASD	1.59 (1.42, 1.77)	<0.0001	1.32 (1.17, 1.48)	<0.0001
IVF vs. Fertile(N=399,421)
1. Relationship between IVF and ASD	1.05 (0.79, 1.40)	0.74	0.92 (0.69, 1.23)	0.58
2. Relationship between IVF and preterm	1.76 (1.59, 1.94)	<0.0001	1.50 (1.35, 1.67)	<0.0001
3. Relationship between preterm and ASD	1.59 (1.43, 1.78)	<0.0001	1.33 (1.18, 1.49)	<0.0001

^aFor the first two assumptions, the unadjusted OR is the crude OR of the association. For the third assumption, the unadjusted OR is the association of ASD (outcome) and preterm (mediator), controlling only for fertility status (exposure)

^bModels adjusted for maternal demographics (maternal paternal age, race, education, marital status, nativity), insurance, smoking, prenatal care, parity, gender, method of delivery, chronic and pregnancy hypertension, gestational and chronic diabetes, breech.

Data with missing covariates are excluded in all models.