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. 2019 Dec 16;26(3):360–368. doi: 10.1093/ibd/izz311

FIGURE 2.

FIGURE 2.

Gene expression changes in proximal colon 24 hours postinfection with Trichuris muris. (A) Genes most significantly upregulated in AKR mice and downregulated in BALB/c mice (red) or downregulated in AKR mice and upregulated in BALB/c mice (blue) following 24 hour Trichuris muris infection. (B) Schematic of the structure of RAGE, showing activating ligands, downstream NF-κB activation, and formation of soluble RAGE (sRAGE) by ADAM10 or MMP9 cleavage. (C) mRNA expression of RAGE in the proximal colon at day 1 postinfection as measured by qPCR. Data generated using Affymetrix Mouse 430 2.0 microarrays analyzed using the puma and TIGERi (TFA illustrator for global explanation of regulatory interactions) packages for Bioconductor; n = 4–5 mice per group. Analysis by Mann-Whitney U test. **P < 0.01.