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. 2020 Jan 27;141(4):313–328. doi: 10.1161/CIRCULATIONAHA.119.042474

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© 2020 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 3. — Most frequent posttranscriptional modifications in regRNAs. Simplified chemical structure of modified RNA nitrogenous bases: purple, pseudouridine [y], reported in the three ncRNAs; pink, N6-methyladenosine [m6A] and N1-methyladenosine [m1A], observed in circRNA and lncRNA; blue, 5-methylcytosine [m5C] and adenosine to inosine editing [A to I], occuring in lncRNA and miRNA. circRNA indicates circular RNA; lncRNA, long non-coding RNA; miRNA, microRNA; and regRNA, regulatory RNA.