TABLE 1.
Baseline characteristics of the participants
| Variables | Total (22 500) | CRC (4689) | TC (1471) | RCC (1220) | LC (12 546) | HCC (2574) | P value |
| Age (years) | 66.9 ± 12.2 | 70.3 ± 12.1 | 55.6 ± 13.9 | 65.3 ± 12.7 | 67.6 ± 11.4 | 64.9 ± 11.0 | <0.001 |
| Female [(n) (%)] | 9724 (43.2) | 1882 (40.1) | 1125 (76.5) | 380 (31.1) | 5768 (46.0) | 569 (22.1) | <0.001 |
| HTN [n (%)] | 5847 (26.0) | 1380 (29.4) | 340 (23.1) | 409 (33.5) | 3072 (24.5) | 646 (25.1) | <0.001 |
| SBP (mmHg) | 127.2 ± 12.5 | 127.3 ± 11.9 | 124.3 ± 12.3 | 130.4 ± 11.9 | 127.6 ± 12.7 | 125.5 ± 12.6 | <0.001 |
| DBP (mmHg) | 77.7 ± 7.5 | 77.2 ± 6.4 | 77.3 ± 7.1 | 79.4 ± 6.8 | 77.9 ± 7.9 | 77.2 ± 7.6 | <0.001 |
| CHD [n (%)] | 1762 (7.8) | 411 (8.8) | 71 (4.8) | 115 (9.4) | 1043 (8.3) | 112 (4.7) | <0.001 |
| HF [n (%)] | 732 (3.3) | 175 (3.7) | 20 (1.4) | 37 (3.0) | 452 (3.6) | 48 (2.0) | <0.001 |
| AF [n (%)] | 950 (4.2) | 265 (5.7) | 28 (1.9) | 50 (4.1) | 530 (4.2) | 77 (3.0) | <0.001 |
| TC (mg/dl) | 191.0 ± 49.0 | 192.0 ± 48.7 | 201.1 ± 46.1 | 190.0 ± 48.6 | 193.9 ± 47.5 | 169.6 ± 53.5 | <0.001 |
| TG (mg/dl) | 138.9 ± 102.4 | 142.9 ± 108.7 | 155.8 ± 118.0 | 162.5 ± 138.0 | 138.9 ± 96.7 | 110.7 ± 79.6 | <0.001 |
| LDL-C (mg/dl) | 112.6 ± 33.9 | 112.9 ± 34.2 | 116.9 ± 31.0 | 111.9 ± 31.7 | 114.3 ± 32.8 | 100.9 ± 38.5 | <0.001 |
| HDL-C (mg/dl) | 43.3. ± 12.6 | 42.9. ± 12.2 | 46.6 ± 12.6 | 41.2 ± 11.3 | 44.4 ± 12.1 | 37.6 ± 14.4 | <0.001 |
| CV risk factors [n (%)] | |||||||
| Dyslipidemia | 5856 (52.6) | 1375 (53.9) | 314 (48.2) | 310 (56.1) | 3072 (49.7) | 785 (65.8) | <0.001 |
| TCh ≥240 mg/dl | 1574 (14.1) | 378 (14.8) | 122 (18.7) | 73 (13.2) | 893 (14.5) | 108 (9.0) | <0.001 |
| LDL-C ≥160 mg/dl | 876 (7.9) | 195 (7.6) | 59 (9.1) | 41 (7.4) | 499 (8.1) | 82 (6.9) | 0.458 |
| HDL-C ≤40 mg/dl | 4585 (41.2) | 1086 (42.5) | 211 (32.4) | 260 (46.9) | 2319 (37.5) | 709 (59.4) | <0.001 |
| Current smoking | 5687 (25.6) | 853 (18.6) | 99 (6.9) | 252 (21.0) | 3580 (28.8) | 903 (35.9) | <0.001 |
| Alcohol consumption | 3243 (15.0) | 587 (13.0) | 64 (4.5) | 157 (13.4) | 1731 (14.4) | 704 (28.6) | <0.001 |
| DM | 3247 (14.4) | 827 (17.6) | 151 (10.3) | 199 (16.3) | 1584 (12.6) | 486 (18.9) | <0.001 |
Continuous variables were expressed using the mean ± SD, and categorical data were presented using frequency and percentage. P values are derived from one-way ANOVA for continuous variables and χ2 for categorical variables among different cancer sites. AF, atrial fibrillation; CHD, coronary heart disease; CRC, colorectal cancer; CV, cardiovascular; DM, diabetes mellitus; HCC, hepatocellular carcinoma; HDL-C, high-density lipoprotein cholesterol; HF, heart failure; HTN, hypertension; LC, lung cancer; LDL-C, low-density lipoprotein cholesterol; RCC, renal cell carcinoma; TC, thyroid cancer; TCh, total cholesterol; TG, triglycerides.