TABLE 3.
Comparison of cardiovascular disease and cardiovascular risk factors between hypertension and without hypertension groups
| Total (22 500) | CRC (4689) | TC (1471) | RCC (1220) | LC (12 546) | HCC (2574) | |||||||
| Variables | HTN (5847) | Non-HTN (16 653) | HTN (1380) | Non-HTN (3309) | HTN (340) | Non-HTN (1131) | HTN (409) | Non-HTN (811) | HTN (3072) | Non-HTN (9474) | HTN (646) | Non-HTN (1928) |
| Age (years) | 72.3 ± 10.6 | 65.1 ± 12.2* | 75.6 ± 9.7 | 68.1 ± 12.4§ | 65.0 ± 10.8 | 52.8 ± 13.5‡ | 70.2 ± 11.2 | 62.9 ± 12.6& | 72.4 ± 10.2 | 66.0 ± 11.3£ | 69.7 ± 10.4 | 63.3 ± 10.7† |
| Female [n (%)] | 2670 (45.7) | 7054 (42.4)* | 623 (45.1) | 1259 (38.0) § | 253 (74.4) | 872 (77.1) | 149 (36.4) | 231 (28.5) & | 1477 (48.1) | 4291 (45.3) £ | 168 (26.0) | 401 (20.8) † |
| CHD [n (%)] | 1243 (21.3) | 519 (3.1)* | 300 (21.7) | 111 (3.4) § | 52 (15.3) | 19 (1.7) ‡ | 88 (21.5) | 27 (3.3) & | 707 (23.0) | 336 (3.5) £ | 96 (14.9) | 26 (1.3) † |
| HF [n (%)] | 465 (8.0) | 267 (1.6)* | 121 (8.8) | 54 (1.6) § | 14 (4.1) | 6 (0.5) ‡ | 32 (7.8) | 5 (0.6) & | 269 (8.8) | 183 (1.9) £ | 29 (4.5) | 19 (1.0) † |
| AF [n (%)] | 565 (9.7) | 385 (2.3)* | 171 (12.4) | 94 (2.8) § | 22 (6.5) | 6 (0.5) ‡ | 35 (8.6) | 15 (1.8) & | 290 (9.4) | 240 (2.5) £ | 47 (7.3) | 30 (1.6) † |
| CV risk factors [i (%)] | ||||||||||||
| Dyslipidemia [n (%)] | 2224 (56.6) | 3632 (50.5)* | 524 (57.1) | 851 (52.1) § | 138 (58.5) | 176 (42.4) ‡ | 167 (63.7) | 143 (49.1) & | 1134 (53.5) | 1938 (47.8) £ | 261 (66.2) | 524 (65.6) |
| LDL (mg/dl) | 113.3 ± 33.9 | 112.2 ± 33.9 | 111.3 ± 33.5 | 113.9 ± 34.7 | 117.4 ± 30.8 | 116.5 ± 31.2 | 114.9 ± 32.9 | 109.1 ± 30.3& | 115.3 ± 33.6 | 113.8 ± 32.3 | 104.0 ± 36.9 | 99.3 ± 39.3† |
| HDL (mg/dl) | 42.0 ± 12.2 | 44.0 ± 12.8* | 41.2 ± 11.9 | 43.8 ± 12.3§ | 44.1 ± 12.2 | 48.0 ± 12.6‡ | 40.1 ± 11.5 | 42.2 ± 11.1& | 43.2 ± 12.0 | 45.0 ± 12.2£ | 37.4 ± 13.0 | 37.6 ± 15.0 |
| TG (mg/dl) | 150.8 ± 111.8 | 132.5 ± 96.2* | 147.7 ± 102.9 | 140.2 ± 111.8 | 171.3 ± 131.2 | 146.9 ± 109.0‡ | 184.4 ± 172.9 | 143.0 ± 92.6& | 150.3 ± 105.2 | 132.9 ± 91.4£ | 125.9 ± 93.7 | 103.2 ± 70.4† |
| TCh (mg/dl) | 191.6 ± 49.2 | 190.8 ± 48.9 | 188.3 ± 48.3 | 194.0 ± 48.8§ | 199.7 ± 45.9 | 201.9 ± 46.2 | 194.2 ± 51.4 | 186.3 ± 45.6 | 194.8 ± 48.8 | 193.4 ± 46.8 | 175.1 ± 50.3 | 166.8 ± 54.8† |
| DM | 1920 (32.8) | 1327 (8.0)* | 488 (35.4) | 339 (10.2) § | 94 (27.6) | 57 (5.0) ‡ | 144 (35.2) | 55 (6.8) & | 949 (30.9) | 635 (6.7) £ | (245)37.9% | 241 (12.5) † |
| Smoking | 1467 (25.4) | 4220 (25.7) | 232 (17.1) | 621 (19.2) | 38 (11.4) | 61 (5.6) ‡ | 87 (21.6) | 165 (20.7) | 884 (28.9) | 2696 (28.7) | 226 (35.5) | 677 (36.1) |
| Alcohol consumption | 892 (15.8) | 2351 (14.8) | 163 (12.2) | 424 (13.4) | 23 (7) | 41 (3.8) ‡ | 157 (15.9) | 94 (12.1) | 1731 (15.4) | 1273 (14.4) | 185 (28.6) | 519 (28.3) |
| UA≥360 μmol/l | 2916 (51.2) | 5884 (36.6)* | 668 (50.4) | 1142 (36.3) § | 127 (38.1) | 263 (24.0) ‡ | 300 (75.6) | 477 (60.4) & | 1506 (50.0) | 3272 (35.5) £ | 315 (50.2) | 730 (39.4) † |
| Creatinine (μmol/l) | 103.7 ± 126.4 | 78.0 ± 61.3* | 107.5 ± 135.3 | 83.0 ± 72.4§ | 77.7 ± 92.0 | 59.4 ± 24.3‡ | 168.3 ± 199.3 | 115.6 ± 109.6& | 95.0 ± 103.1 | 74.7 ± 53.3£ | 110.4 ± 149.1 | 80.5 ± 56.5† |
Continuous variables were expressed using the mean ± SD, and categorical data were presented using frequency and percentage. P values are derived from t-test for continuous variables and χ2 for categorical variables; *,§, ‡, &, £ and † means P < 0.05 among total and different cancers when compared the group with HNT and without HTN. AF, atrial fibrillation; CHD, coronary heart disease; CRC, colorectal cancer; CV, cardiovascular; DM, diabetes mellitus; HCC, hepatocellular carcinoma; HDL-C, high-density lipoprotein cholesterol; HF, heart failure; HTN, hypertension; LC, lung cancer; LDL-C, low-density lipoprotein cholesterol; RCC, renal cell carcinoma; TC, thyroid cancer; TCh, total cholesterol; TG, triglycerides; UA, uric acid.