Table 2.
Cortical degeneration and tau inclusion burden
| Subregion | Tau score | Neurodegeneration score | Composite tau + neurodegeneration score | Regional atrophy score | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Frontal | Perirolandic | PTO | Frontal | Perirolandic | PTO | Frontal | Perirolandic | PTO | Frontal | Perirolandic | PTO | |
| Midbrain subjects | ||||||||||||
| bvFTD-PiD (n = 7) | 2.1 ± 0.2 | 0.8 ± 0.4 | 1.8 ± 0.4 | 3.5 ± 0.8 | 0.5 ± 0.6 | 2.5 ± 1.0 | 5.0 ± 0.9 | 1.3 ± 0.8 | 4.0 ± 1.1 | 3.5 ± 1.6 (n = 7) | 0.6 ± 1.4 (n = 7) | 2.6 ± 1.3 (n = 7) |
| bvFTD-CBD (n = 4) | 2.0 ± 0.2 | 1.6 ± 0.2 | 1.6 ± 0.1 | 1.6 ± 0.1 | 1.0 ± 0.9 | 0.8 ± 0.5 | 2.8 ± 0.5 | 2.6 ± 1.1 | 2.1 ± 0.8 | 2.4 ± 0.9 (n = 4) | 1.1 ± 0.9 (n = 4) | 1.0 ± 0.9 (n = 4) |
| bvFTD- FTLD-tau/MAPT (n = 3) | 1.4 ± 0.1 | 0.8 ± 0.6 | 1.2 ± 0.1 | 3.7 ± 1.0 | 0.8 ± 0.6 | 2.8 ± 0.4 | 4.7 ± 1.0 | 1.6 ± 0.7 | 4.0 ± 0.4 | 4.2 (n = 1) | 2.6 (n = 1) | 2.8 (n = 1) |
| bvFTD-overall (n = 14) | 1.9 ± 0.3 | 1.0 ± 0.5 | 1.7 ± 0.4 | 3.0 ± 1.2 | 0.7 ± 0.7 | 2.1 ± 1.1 | 4.3 ± 1.2 | 1.7 ± 1.0 | 3.5 ± 1.2 | 3.2 ± 1.4 (n = 12) | 0.9 ± 1.3 (n = 12) | 2.1 ± 1.3 (n = 12) |
| CBS-PiD (n = 2) | 2.2 ± 0.0 | 1.8 ± 0.6 | 1.3 ± 0.3 | 3.5 ± 0.6 | 2.9 ± 1.6 | 2.5 ± 0.3 | 4.7 ± 0.6 | 4.7 ± 2.2 | 3.8 ± 0.6 | 3.1 ± 1.9 (n = 2) | 2.7 ± 0.5 (n = 2) | 2.5 ± 1.4 (n = 2) |
| CBS-CBD (n = 3) | 1.5 ± 0.2 | 1.6 ± 0.3 | 0.9 ± 0.1 | 0.8 ± 0.6 | 2.1 ± 0.6 | 0.4 ± 0.5 | 1.6 ± 0.6 | 3.7 ± 0.3 | 1.2 ± 0.5 | 1.4 ± 0.4 (n = 2) | 1.8 ± 0.3 (n = 2) | 1.2 ± 0.2 (n = 2) |
| CBS-overall (n = 5) | 1.8 ± 0.4 | 1.7 ± 0.4 | 1.1 ± 0.3 | 1.9 ± 1.6 | 2.4 ± 1.0 | 1.2 ± 1.2 | 2.8 ± 1.8 | 4.1 ± 1.2 | 2.2 ± 1.5 | 2.2 ± 1.5 (n = 4) | 2.2 ± 0.6 (n = 4) | 1.8 ± 1.1 (n = 4) |
| Pons subjects | ||||||||||||
| bvFTD-PiD (n = 6) | 2.1 ± 0.3 | 0.8 ± 0.4 | 1.8 ± 0.4 | 3.5 ± 0.9 | 0.6 ± 0.7 | 2.6 ± 1.1 | 4.9 ± 0.9 | 1.4 ± 0.9 | 4.0 ± 1.2 | 3.4 ± 1.7 (n = 6) | 0.6 ± 1.5 (n = 6) | 2.7 ± 1.4 (n = 6) |
| bvFTD-CBD (n = 5) | 2.0 ± 0.2 | 1.5 ± 0.3 | 1.6 ± 0.1 | 1.6 ± 0.2 | 0.9 ± 0.8 | 0.9 ± 0.5 | 2.7 ± 0.5 | 2.4 ± 1.0 | 2.2 ± 0.7 | 2.4 ± 0.9 (n = 4) | 1.1 ± 0.9 (n = 4) | 1.0 ± 0.9 (n = 4) |
| bvFTD- FTLD-tau/MAPT (n = 3) | 1.4 ± 0.1 | 0.8 ± 0.6 | 1.2 ± 0.1 | 3.7 ± 1.0 | 0.8 ± 0.6 | 2.8 ± 0.4 | 4.7 ± 1.0 | 1.6 ± 0.7 | 4.0 ± 0.4 | 4.2 (n = 1) | 2.6 (n = 1) | 2.8 (n = 1) |
| bvFTD-overall (n = 14) | 1.9 ± 0.3 | 1.1 ± 0.5 | 1.6 ± 0.4 | 2.9 ± 1.2 | 0.8 ± 0.7 | 2.0 ± 1.2 | 4.1 ± 1.3 | 1.8 ± 0.9 | 3.4 ± 1.2 | 3.1 ± 1.4 (n = 11) | 1.0 ± 1.3 (n = 11) | 2.1 ± 1.4 (n = 11) |
| CBS-PiD (n = 2) | 2.2 ± 0.0 | 1.8 ± 0.6 | 1.3 ± 0.3 | 3.5 ± 0.6 | 2.9 ± 1.6 | 2.5 ± 0.3 | 4.7 ± 0.6 | 4.7 ± 2.2 | 3.8 ± 0.6 | 3.1 ± 1.9 (n = 2) | 2.7 ± 0.5 (n = 2) | 2.5 ± 1.4 (n = 2) |
| CBS-CBD (n = 9) | 1.4 ± 0.4 | 1.6 ± 0.4 | 0.9 ± 0.3 | 0.9 ± 0.6 | 1.8 ± 0.5 | 0.5 ± 0.5 | 1.6 ± 0.7 | 3.4 ± 0.7 | 1.2 ± 0.6 | 1.4 ± 0.6 (n = 7) | 2.0 ± 0.8 (n = 7) | 1.0 ± 0.7 (n = 7) |
| CBS-overall (n = 11) | 1.6 ± 0.5 | 1.6 ± 0.4 | 0.9 ± 0.3 | 1.3 ± 1.2 | 2.0 ± 0.8 | 0.8 ± 0.9 | 2.2 ± 1.4 | 3.6 ± 1.1 | 1.6 ± 1.2 | 1.8 ± 1.2 (n = 9) | 2.2 ± 0.8 (n = 9) | 1.3 ± 1.0 (n = 9) |
bvFTD behavioral variant of frontotemporal dementia, CBD corticobasal degeneration, CBS corticobasal syndrome, FTLD frontotemporal lobar degeneration, MAPT microtubule-associated protein tau, PiD Pick’s disease, PTO parieto-temporooccipital