Table 3. Comparison of the structural features (variables) used for the analysis of hCG samples.
| Structural feature/Variable | EP-hCG mean±SEM | LP-hCG mean±SEM | Paired t-test (1) | GTD-hCG mean±SEM | Ind. t-test (2) |
|---|---|---|---|---|---|
| High mannose | 40.4±21.1 | 28.5±9.4 | 0.417 | 2.2±0.9 | (3) |
| Mono-antennary | 17.7±5.0 | 9.0±0.3 | 0.238 | 22.3±2.4 | 0.402 |
| Bi-antennary | 56.7±3.0 | 62.6±1.2 | 0.113 | 66.0±1.6 | (3) |
| Tri-antennary | 21.8±1.9 | 24.9±0.9 | 0.299 | 10.9±2.0 | 0.013 |
| Tetra-antennary | 3.8±1.1 | 3.5±0.5 | 0.766 | 0.7±0.4 | 0.030 |
| Agalactosylated | 24.7±6.6 | 30.0±1.7 | 0.401 | 5.8±2.1 | 0.092 |
| Bisected | 23.6±1.4 | 44.9±3.1 | 0.006 | 6.4±2.0 | 0.001 |
| Core-fucosylated | 60.4±5.6 | 66.7±2.2 | 0.473 | 34.1±1.5 | 0.003 |
| LacNAc | 62.4±4.0 | 67.7±1.0 | 0.344 | 18.8±4.6 | 0.001 |
| NeuAc | 27.2±2.8 | 17.6±2.9 | 0.232 | 79.4±4.9 | 0.001 |
| LewisX | 10.4±2.1 | 14.7±2.5 | 0.131 | 1.8±.0.4 | 0.005 |
Mean values ± standard error of the mean (SEM) of the structural features (variables) used for the analysis of hCG samples, t-test for paired EP-hCG vs LP-hCG samples, and t-test for independent EP-hCG vs GTD-hCG samples (full data, see tables in S3–S6 Tables). Values in bold correspond to variables significant after correction for multiple comparison according to Bonferroni test
(1) Paired t-test of EP-hCG vs LP-hCG samples.
(2) Independent t-test of EP-hCG vs GTD-hCG samples.
(3) High mannose and bi-antennary N-glycans did not meet normality test in the Independent t-test.