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. 2019 Apr 24;105(2):366–374. doi: 10.3324/haematol.2019.217950

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Figure 1. — Relation of KIT D816V allele burden in formalin-fixed paraffin-embedded (FFPE) bone marrow (BM) sections of systemic mastocytosis (SM) patients with that in liquid specimens. (A) Ternary plot of KIT D816V variant allele frequency (VAF) from 54 paired FFPE BM section (red axis), BM aspirate (green axis) and peripheral blood (PB) (blue axis) samples. (B) Comparison of KIT D816V VAF in 108 paired FFPE BM (VAF) tissue] and BM aspirate/PB samples (VAF liquid) showing a systematic constant and proportional deviation to higher VAF in the tissue (r=0.87; slope: 0.59 (95%CI: 0.52-0.65), intercept: 1.72 (95%CI: 1.53-1.91) for log transformed data). (C) Bland-Altman plot of KIT D816V VAF in the tissue and liquid specimens showing a skewing towards higher results in the tissue for samples with low average VAF.