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. 2019 May 16;105(2):375–386. doi: 10.3324/haematol.2018.209650

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Figure 3. — Rkip deletion causes increased myeloid lineage commitment in a murine model by increasing the sensitivity to granulocyte-macrophage colony-stimulating factor (GM-CSF). (A) To assess the effects of GM-CSF in vivo, four mice with a deletion of Rkip (Rkip⁻^/⁻), as well as four control mice (Rkip^+/+) were injected intraperitoneally with 500ng GM-CSF twice a day for four days and were analyzed on day 5. (B) Cytological analysis of peripheral blood smears from these mice revealed a significant increase in the number of myelomonocytic cells (MMC) in Rkip⁻^/⁻ animals. A representative peripheral blood smear picture is shown. Lymphoid cells are shown as LYM. Graphs show the average ±Standard Deviation (SD). Statistical significance was evaluated by Student’s t-test. (C) Representative flow cyto-metric plots of the mice presented in (B) showing an increased percentage of CD11b⁺ and CD11b⁺ Ly6G⁺ cells in the bone marrow (BM), peritoneal cavity (PC), and peripheral blood (PB) of Rkip⁻^/⁻ mice. Graphs show the average ±SD. Statistical significance was evaluated by Student’s t-test. RKIP: RAF kinase inhibitor protein.