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Scheme summarizing the mechanisms of fibrin(ogen) as a friend (in green) and foe (in red) in human disease. Square boxes represent abnormalities that prompt fibrinogen involvement in illness settings. CNS: central nervous system; CVD: cardiovascular diseases; FCP: fibrinogen cleavage products; HFD: high-fat diet; MMP-2: matrix metalloproteinase 2; PTM: post-translational modifications; TLR4: toll-like receptor 4.
