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. 2019 May 17;105(2):387–397. doi: 10.3324/haematol.2019.219394

Figure 2.

Figure 2.

Rough eye phenotype induced by overexpression of human BCR-ABL1p210/T315I. Light (A-D, M-N) and scanning electron (E-L, O-R) micrographs of adult Drosophila melanogaster compound eyes expressing BCR-ABL1P210/T315I under the control of the eye specific promoter GMR-GAL4. Flies were raised on 18°C, 25°C or 29°C. I-L and Q-R are high magnifications of the centremost region of E-H and O-P respectively (1,370x). GMR-GAL4>w1118 were used as control. Ommatidial facets are depicted in (I) by (*), misplaced mechanosensory bristles in (J) depicted by arrowheads and ommatidial fusions in (Q) are shown by arrow. Posterior is to the left. Lower right panel represents quantification of severity of roughness of the adult fly eye using a grading scale. Genotypes indicated are under the control of eye specific promoter GMR-GAL4. Data represents mean ± SEM. ****, P<0.0001.