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. 2019 May 17;105(2):387–397. doi: 10.3324/haematol.2019.219394

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Figure 4. — Imatinib shows a tendency to decrease BCR-ABL1^p210 mediated eye defect. Scanning electron micrographs (A-X) of adult Drosophila compound eyes from flies fed on 0.3% DMSO only or imatinib. Posterior is to the left. GMR-GAL4>^w1118 were used as control. A-F are high magnification of the posterior end of the eye in G-L and S-X respectively (692 x). Normal development in control flies fed on DMSO or imatinib is observed. BCR-ABL1^p210 (D, J) and BCR-ABL1^p210/T315I (P, V) expressing flies fed on DMSO show characteristic defective area with loss of ommatidial facets. Area is marked with a representative dashed line. Feeding low or high dose imatinib to BCR-ABL1^p210 (E, K, F, L) and BCR-ABL1^p210/T315I (Q, W, R, X) retained the defective area in the posterior end of the eye marked with a dashed line. Compare to D, J and P, V respectively. Lower panel represents measurement of the posterior eye defect area (mm²). Data represents mean ± SEM. ^****, P<0.0001.