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. 2019 May 17;105(2):387–397. doi: 10.3324/haematol.2019.219394

Figure 7.

Figure 7.

Dasatinib and ponatinib rescue BCR-ABL1p210 driven eye defect in a dose dependent manner. Scanning electron micrographs of adult Drosophila compound eyes from flies expressing BCR-ABL1p210 and fed on 0.03% DMSO (A, E), 1 mM (B, F), 10 mM (C-G) or 20 mM (D, H) dasatinib and flies fed on 0.3% DMSO (I, L), 28 μm pona-tinib (J, M) or 280 mM ponatinib (K, N). Posterior is to the left. E-H and L-N are high magnification of the posterior end of the eye in A-D and I-K respectively (692x). Posterior eye defect area is marked with a representative dashed line. Lower panels represent measurement of the posterior eye defect area (mm2) . Data represents mean ± SEM. ** P<0.01; **** P<0.0001.