Figure 10. Numerical simulations of Model 2.

Responses of the neurons normalized to baseline vs. the intensity of the laser, ${\Gamma }_{opto}$ . (A) Activities of PCs and PV neurons: for small ${\Gamma }_{opto}$ , the PV response is paradoxical and the suppression of the PC and PV population activities relative to baseline are the same. (B) Activities of SOM and X neurons. Color code as in Figure 9. Thick lines: population averaged responses. Thin lines: responses of 10 neurons randomly chosen in each population. Firing rates were estimated over 100s. Parameters: K = 500, N = 76800. Other parameters as in Tables 6–7. The baseline activities are: r_E  = 4.2 Hz, r_I  = 6.8 Hz r_S  = 7.0 Hz, r_X  = 3.9 Hz.

Figure 10—figure supplement 1. Model 2.

Robustness with respect to change in the average connectivity, K. Triangles: K = 500; cross: K = 1000; circles: K = 2000. N _α = 10000 neurons per population. Color code and parameters as in Figure 10. Baseline firing rates: K = 500: r_E  = 4.2 Hz r_I  = 7.0 Hz, r_S  = 7.0 Hz, r_X  = 4.0 Hz, K = 1000: r_E  = 4.0 Hz, r_I  = 6.8 Hz, r_S  = 6.8 Hz, r_X  = 3.8 Hz; K = 2000: r_E  = 3.7 Hz, r_I  = 6.8 Hz, r_S  = 6.7 Hz, r_X  = 3.8. Rates are averaged over 10s.

Figure 10—figure supplement 2. Model 2.

Robustness to a change of ±10% in the interaction parameters. (A) Distribution of the population activities. (B) Distribution of the activity changes upon stimulation for ${\Gamma }_{opto}=0.07mW.m{m}^{-2}$ . Rates are averaged over 10s. Color code as in Figure 10.

Figure 10—figure supplement 3. Model 2.

Firing statistics at baseline. (A) Distribution of the firing rates (mean: r_E  = 4.5 HZ, r_I  = 10.6 Hz, r_S  = 7.2 hz, r_V  = 4.9 Hz). (B) Distribution of CV. Individual rates are average over 100s with a threshold at 0.05Hz. CVs are computed over 30s. Color code and parameters as in Figure 10.