| 1 Failure to close a patent ductus arteriosus (PDA) after 1 course of ibuprofen |
1 |
111 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.18 [0.88, 1.58] |
| 2 Reopening of PDA |
1 |
111 |
Risk Ratio (M‐H, Fixed, 95% CI) |
3.05 [0.33, 28.47] |
| 3 Need for surgical ligation |
1 |
111 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.28 [0.08, 0.94] |
| 4 Mortality (in hospital) |
1 |
111 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.02 [0.07, 15.87] |
| 5 Chronic lung disease (at 36 weeks' postmenstrual age) |
1 |
111 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.10 [0.55, 2.20] |
| 6 Retinopathy of prematurity (any stage) |
1 |
111 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.68 [0.39, 1.19] |
| 7 Retinopathy of prematurity (stage 3 or 4) |
1 |
111 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.34 [0.04, 3.16] |
| 8 Intraventricular haemorrhage (any grade) |
1 |
111 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.73 [0.25, 2.15] |
| 9 Intraventricular haemorrhage (grade III and IV) |
1 |
111 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.34 [0.01, 8.15] |
| 10 Periventricular leukomalacia (cystic) |
1 |
111 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.51 [0.05, 5.45] |
| 11 Necrotising enterocolitis |
1 |
111 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.44 [0.12, 1.60] |
| 12 Isolated intestinal perforation |
1 |
111 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.04 [0.19, 21.82] |
| 13 Oliguria (urine output ≤ 1 mL/kg/hour) |
1 |
111 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.51 [0.05, 5.45] |
| 14 Serum/plasma creatinine after treatment (µmol/L) |
1 |
111 |
Mean Difference (IV, Fixed, 95% CI) |
2.10 [‐4.92, 9.12] |
| 15 Gastrointestinal haemorrhage |
1 |
111 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.51 [0.16, 1.59] |
