Comparison 10. Rectal ibuprofen versus oral ibuprofen.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure to close a PDA after 3 doses	1	72	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.28, 2.49]
2 Need for surgical ligation	1	72	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.15, 6.72]
3 Plasma creatinine (µmol/L	1	72	Mean Difference (IV, Fixed, 95% CI)	‐6.18 [‐7.22, ‐5.14]
4 Plasma bilirubin (µmol/L) after treatment	1	72	Mean Difference (IV, Fixed, 95% CI)	7.01 [‐11.23, 25.25]
5 Urine output (mL/kg/hr) after treatment	1	72	Mean Difference (IV, Fixed, 95% CI)	‐0.22 [‐0.45, 0.01]