Salama 2008.

Methods	Single centre, randomised controlled trial conducted in Doha, State of Qatar. Study period: January 2005 to March 2007
Participants	41 preterm infants (PMA, 34 weeks, BW < 2500 grams) diagnosed with haemodynamically significant PDA confirmed by ECHO Ibuprofen: 21 infants, mean (SD) PMA 27.7 (2.5); BW 1094 (480) grams Indomethacin: 20 infants, mean (SD) PMA 27.8 (2.8) weeks; BW 1050 (440) grams
Interventions	Ibuprofen: oral 10 mg/kg on the first day followed by 5 mg/kg for 2 more days. Ibuprofen was mixed with 0.5 mL of milk before its administration via an oro‐gastric tube Indomethacin: IV 3 doses of 0.2 mg/kg/dose every 24 hours
Outcomes	Primary outcome: complete closure of the PDA Secondary outcomes: need for surgical ligation, bowel perforation, and mortality
Notes	No information on funding provided
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomisation was conducted according to a pre designed simple block randomisation table 'A' for indomethacin and 'B' for ibuprofen (AABABBBBAA, BBBAAABBA, AABBABABAAB, etc.)
Allocation concealment (selection bias)	Unclear risk	No description of possible concealment
Blinding of participants and personnel (performance bias) All outcomes	High risk	Indomethacin was given IV and ibuprofen was given via an oro‐gastric tube
Blinding of outcome assessment (detection bias) All outcomes	High risk	"The paediatric cardiologist was aware of patient's group allocation"
Incomplete outcome data (attrition bias) All outcomes	Low risk	Outcomes reported on all randomised infants
Selective reporting (reporting bias)	Unclear risk	Study protocol was not available to us so we could not ascertain if there were deviations from the protocol
Other bias	Low risk	Appeared free of other bias