Supapannachart 2002.

Methods	Single centre, randomised, controlled trial conducted in Bangkok, Thailand. Study period: 1 April 2000 to 31 August 2001
Participants	18 preterm infants (< 34 weeks' GA) with symptomatic PDA Ibuprofen: 9 infants, mean (SD) GA 30.1 (2.7); BW 1447 (39) g; 8 boys, 1 girl Indomethacin: 9 infants, mean (SD) GA 30.4 (2.6); BW 1432 (531) g; 6 boys, 3 girls
Interventions	Ibuprofen: orally 10 mg/kg/dose for 3 doses at 24‐hour intervals Indomethacin: oral or IV 0.2 mg/kg/dose for 3 doses given at 12‐hour intervals
Outcomes	PDA closure rate, duration of ventilatory support, CLD (age not stated), IVH (grade not stated), NEC, and mortality
Notes	No information on funding provided
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information provided
Allocation concealment (selection bias)	Low risk	Sealed envelopes were used for allocation
Blinding of participants and personnel (performance bias) All outcomes	High risk	Ibuprofen and indomethacin were given at different times
Blinding of outcome assessment (detection bias) All outcomes	High risk	Ibuprofen and indomethacin were given at different times
Incomplete outcome data (attrition bias) All outcomes	Low risk	Outcomes reported for all infants randomised
Selective reporting (reporting bias)	Unclear risk	Study protocol was not available to us so we could not ascertain if there were deviations from the protocol
Other bias	Low risk	Appeared free of other bias