ChiCTR‐TRC‐14004719.

Trial name or title	Developmental pharmacokinetics and pharmacodynamics of chiral ibuprofen associated with the CYP2C8/9 gene polymorphism in premature infants with PDA
Methods	Randomised controlled trial
Participants	Preterm newborns, with PDA
Interventions	Objectives of the study: study the pharmacodynamic process by oral S‐ibuprofen and ibuprofen to determine the superiority of administration of S‐ibuprofen. "The first day the experimental group given 10 mg/kg, next 5 mg/kg, 5 mg/kg third regimen" "The first day the control group given 10 mg/kg, next 5 mg/kg, 5 mg/kg third regimen"
Outcomes	Plasma concentrations of ibuprofen. Clinical outcomes not stated
Starting date	Registered May 2014
Contact information	Li Zhiping, 399 Wanyuan Road, Minhang, Shanghai, China. Email: zhipinglifudan@yeah.net
Notes	As of November 2016, the study was ongoing. This study is also registered as ChiCTR‐TRC‐14004559