NCT01758913.

Trial name or title	Closure of patent ductus arteriosus with indomethacin or ibuprofen in extreme low‐birth‐weight infants
Methods	Randomised controlled trial
Participants	Selection criteria: preterm infants with birth weight < 1000 g, radiographic diagnosis of respiratory distress syndrome, requirement of mechanical ventilation, and ECHO and clinical evidence of significant PDA
Interventions	Indomethacin: 56 infants, indomethacin 0.2 mg/kg, 0.1 mg/kg and 0.1 mg/kg in 24‐hour interval Ibuprofen: 54 infants, ibuprofen 10 mg/kg, 5 mg/kg and 5 mg/kg in 24‐hour interval
Outcomes	Serum electrolytes, creatinine, renal function (urine output, glomerular filtration rate, fractional excretion of sodium and potassium, osmolar clearance and free water clearance, urinary prostaglandin excretion), pulmonary outcome, and mortality
Starting date	February 2007
Contact information	Tsu‐Fu Yeh, M.D., Ph.D., Taipei Medical University
Notes	ClinicalTrials.gov identifier: NCT01758913 As of January 3, 2013, the recruitment for this study was completed