Table 2.
Pre-Angiography Plasma and Urine Biomarker Levels by MAKE-D Status
| Plasma Biomarker | Urine Biomarker | |||||||
|---|---|---|---|---|---|---|---|---|
| Median [IQR], pg/mL | P | Median [IQR, pg/mL | P | |||||
| MAKE-D | No MAKE-D | Unadj | Adj* | MAKE-D | No MAKE-D | Unadj | Adj* | |
| KIM-1 | 504 (306, 948) | 321 (189, 585) | <0.001 | 0.04 | 1804 (961,3558) | 1392 (720, 2743) | 0.06 | 0.2 |
| NGAL | 259 (209, 420) | 228 (173, 296) | 0.001 | 0.04 | 37 (16, 97) | 23 (11, 49) | 0.009 | 0.09 |
| IL-18 | 332 (238, 446) | 318 (246, 408) | 0.5 | 0.9 | 33 (16, 54) | 21 (12, 37) | 0.003 | 0.01 |
| MCP-1 | 229 (167, 280) | 217 (181,270) | 0.9 | 0.9 | 289 (159, 565) | 205 (118, 363) | 0.01 | 0.1 |
| UMOD | 59 (41,81) | 71 (51, 97) | 0.006 | 0.01 | 2300 (1462, 3642) | 2484 (1554, 3944) | 0.5 | 0.9 |
| YKL-40 | 141987 (98750, 284819) | 91371 (53545, 174700) | <0.001 | 0.001 | 902 (272, 4474) | 394 (127, 1184) | <0.001 | 0.02 |
Urine creatinine-corrected results in Table S1
*
Adjusted for Urinary Albumin-Creatinine Ratio and baseline eGFR
Adj, adjusted; unadj, unadjusted; KIM-1 [kidney injury marker 1], NGAL [neutrophil gelatinase-associated lipocalin], IL-18 [interleukin 18], MCP-1 [monocyte chemoattractant protein 1], UMOD [uromodulin], and YKL-40 [chitinase-3-like protein 1]; MAKE-D, major adverse kidney events and death.