Table 2:
Final weights and blood and urine biochemistries†
| 20-weeks-old | 30-weeks-old | P-Values | ||||||
|---|---|---|---|---|---|---|---|---|
| NL | CKD | NL | CKD | ANOVA Model |
Age (20 vs 30) |
Disease (CKD vs NL) |
Age x Disease |
|
|
Body weight
(g) |
487.9 (5.4) b
n = 24 |
460.2 (6.1) c
n = 24 |
546.3 (7.7)a
n = 24 |
511.0 (5.9) b
n = 23 |
< 0.0001 | < 0.0001 | < 0.0001 | 0.55 |
|
Kidney
weight (g) |
1.7 (0.02) c
n = 22 |
2.1 (0.05) b
n = 22 |
1.8 (0.03) c
n = 24 |
2.7 (0.09) a
n = 23 |
< 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 |
|
Plasma P (mg/dL) |
6.1 (0.4) n = 22 |
6.0 (0.3) n = 21 |
6.6 (0.4) n = 22 |
6.2 (0.4) n = 21 |
0.74 | 0.42 | 0.56 | 0.63 |
|
Plasma Ca (mg/dL) |
5.5 (0.2) n = 22 |
5.6 (0.2) n = 21 |
6.3 (0.2) n = 22 |
5.7 (0.4) n = 21 |
0.12 | 0.09 | 0.37 | 0.14 |
|
Plasma Creatinine (mg/dL) |
0.45 (0.02) c
n = 23 |
0.78 (0.03) b
n = 23 |
0.45 (0.02) c
n = 23 |
0.92 (0.06) a
n = 22 |
<0.0001 | 0.06 | <0.0001 | 0.056 |
|
Urine Creatinine (mg/day)* |
14.4 (0.7) bc
n = 24 |
12.3 (0.5) c
n = 24 |
17.4 (0.6) a
n = 24 |
14.8 (0.5) b
n = 23 |
<0.0001 | <0.0001 | 0.0001 | 0.72 |
|
Creatinine
Clearance (mL/min) |
2.55 (0.36) a
n = 24 |
1.18 (0.07) b
n = 24 |
2.85 (0.24) a
n = 23 |
1.35 (0.10) b
n = 22 |
<0.0001 | 0.08 | <0.0001 | 0.50 |
|
Plasma BUN (mg/dL) |
15.0 (0.4) c
n = 22 |
32.3 (0.7) b
n = 21 |
15.7 (0.9) c
n = 22 |
37.0 (1.3) a
n = 21 |
<0.0001 | 0.003 | <0.0001 | 0.02 |
|
Hematocrit
(%) |
49.5 (10.1) a
n = 24 |
43.3 (9.2) b
n = 22 |
49.5 (10.1) a
n = 24 |
42.4 (8.8) b
n = 23 |
<0.0001 | 0.53 | <0.0001 | 0.07 |
|
Plasma PTH (pg/mL) |
773.4 (69.9) b
n = 24 |
873.8 (68.0) b
n = 24 |
877.1 (64.8) b
n = 24 |
1849.2 (239.2) a
n = 22 |
<0.0001 | <0.0001 | <0.0001 | 0.008 |
|
Plasma
iFGF23 (pg/mL) |
527.0 (24.5) c
n = 24 |
841.0 (49.7) b
n = 24 |
527.0 (24.5) c
n = 24 |
2345.8 (276.9) a
n = 22 |
<0.0001 | <0.0001 | <0.0001 | <0.0001 |
|
Plasma
1,25D (pmol/L) |
278.6 (37.4) a
n = 24 |
259.2 (36.3) a n = 24 |
230.5 (37.4) a n = 24 |
96.1 (22.1) b n = 23 |
0.0005 | 0.001 | 0.02 | 0.07 |
†
Final weights, and blood and urine biochemistries.
ANOVA p-values for the overall model (PModel), main effect of age (PAge), main effect of disease (PDisease), and interaction of age and disease (PAxD) are shown, and means and (SEM) are shown for each group. Different letters represent group differences.
*
average 24 hour urine creatinine (mg/day) over 4-day balance period.