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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Neurourol Urodyn. 2020 Jan 9;39(2):507–522. doi: 10.1002/nau.24265

Table 3.

Summary of Pooled Bladder Function Measurements with Normative Reference Values

Studies
(N)
Total
Sample
Mean
Range of
Individual
Studies
Overall Estimate
(95% CI)
I2
%
90%
Normative
Reference
Value1
Urination Frequencies2
Daytime frequency 5 869 5.6-7.2 6.6 (6.2, 7.0) 85.9 4-10
Nighttime frequency 5 869 0.1-1.0 0.4 (0.0, 0.8) 99.0 0-2
24-hour frequency 7 1406 5.8-8.3 7.0 (6.3, 7.7) 97.5 4-12
Voided and Postvoid Residual Volumes3
Total daytime voided volume 4 854 273-1261 945 (289, 1601) 99.6 136-1718
Mean daytime voided volume 4 140 207-289 230 (203,258) 61.1 108-418
Total nighttime voided volume 4 854 347-468 401 (343, 459) 91.5 152-743
Mean nighttime voided volume 5 259 155-450 317 (225, 408) 97.1 44-588
24-hour voided volume 7 1424 1256-1759 1577 (1428, 1725) 94.0 761-3042
Mean voided volume 7 838 216-294 245 (226, 265) 85.7 116-428
Maximum voided volume 5 767 362-514 425 (363, 487) 95.6 184-761
Minimum voided volume 2 280 81-193 137 (27, 246) 98.9 34-325
Postvoid residual volume 4 503 1-20 12 (4, 20) 99.9 1-56
Uroflowmetry Parameters3,4,5
Maximum flow rate (Qmax) 11 1169 20-49 29 (26, 32) 97.9 12-44
Mean flow rate (Qave) 9 860 9-24 15 (12, 18) 99.3 6-26
Time to maximum flow (TQMax) 5 399 7-15 10 (8, 12) 90.4 3-20
Flow time (Tvv) 7 517 24-38 28 (23, 33) 94.6 13-64
Voided volume (VV) 11 1067 224-409 324 (299, 350) 99.2 121-638
1

Reference values rounded to whole numbers

2

Frequency counts rounded to tenths

3

Volumes reported in milliliters

4

Flow rates in milliliters per seconds

5

Flow time in seconds