Table 1.

Sclerosing Epithelioid Fibrosarcoma with YAP1 and/or KMT2A rearrangements

	Age/Sex	Location (depth)	Size (cm)	Mitotic count (10HPF)	Genetics			Follow-up
					RNAseq & RT-PCR (exon number)	YAP1 FISH	KMT2A FISH
1	45/F	Paraspinal (deep)	2.6	P: 0 R1: 1	YAP1(5)-KMT2A(4)#	NEG (1X)	NEG	Recur (1yr)
2	45/F	Thigh (subcutis)	3.4	P:17 Mets: 21	YAP1(4)-KMT2A(5)#	NEG (1X)	NEG	Mets to soft tissue (1.5yr)
3	47/M	Lower leg (deep)	2.0	P: NA R1: 5 R2: 0 R3: 2	YAP1(5)-KMT2A(4)#†	POS	NEG	Recur (10, 17, 21 yr)
4	73/F	Iliopsoas muscle (deep)	10	8	ND	NEG (1X)	POS	DOD (1yr), mets to contralateral pelvis & scalp
5	35/M	Chest wall (deep)	5.0	3	ND	NEG	POS*	Recent
6	10/F	Frontal dura (deep)	12	9	ND	NEG	POS	NED (2.5yr)
7	86/M	Inguinal (NA)	NA	11	ND	POS	NEG	NA
8	42/M	Thigh (subcutis)	2.5	4	YAP1(5)-KMT2A(4) †	NEG	NEG	Recent
9	22/M	Neck/paraspinal (deep)	8	4	KMT2A(6)-YAP1(9)‡	NEG (1X)	NEG (1X)	AWD (1yr)

^*MAML2 FISH also positive for rearrangement

^#RNAseq

^†RT-PCR, (parenthesis are exonic breakpoint)

^‡MSK-IMPACT; F, female; HPF, high power fields; M, male; mets, metastasis; NA, not available; ND, not done; NEG, negative; P, primary tumor; POS, positive; R1, first recurrence; R2, second recurrence; R3, third recurrence; RNAseq, RNA sequencing; RT-PCR, reverse transcription polymerase chain reaction; yr, year(s); 1X, only one copy of fused signals.