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. 2020 Feb 5;8:1. doi: 10.3389/fcell.2020.00001

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Copyright © 2020 Zhang, Fan, Cai, Zhang, Zuo, Zhu, Cao, Zhang, Liu, Chen and Liang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ang II-induced renal fibrosis in rats. SD rats were treated with Ang II infusion as describe. (A,B) Immunohistochemical staining and quantification of alpha-SMA in kidney (N = 6). **p < 0.01 vs. Con. (C,D) Representative immunohistochemical staining of MMP-2 in kidney (N = 6). **p < 0.01 vs. Con. (E,F) Immunostaining of MMP-9 in kidney. Representative photomicrographs from Ang II infusion rats (N = 6). **p < 0.01 vs. Con. (G,H) Immunohistochemical staining and quantification of TGF-beta in kidney (N = 6). **p < 0.01 vs. Con.