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. 2020 Feb 11;10:2351. doi: 10.1038/s41598-020-59172-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pressure effects on binding free energy. (a) Dissociation free energy profiles as a function of d calculated by PaCS-MD/MSM. Red open and filled triangles indicate the borders between Phases 1–2 and 2–3, respectively. (b) Standard binding free energies calculated from the free energy profiles and volume correction ( $Δ G_{b i n d}^{°}$ ) and binding free energies before volume correction (ΔG_bind).