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. 2020 Feb 11;10:2326. doi: 10.1038/s41598-020-59092-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Acute scratch behaviour in Na_V1.7^−/−, Na_V1.8^−/−, Na_V1.9^−/− and wild type mice upon intradermal injection of pruritogens. (a–k) Scratch events within 30 min after intradermal injection (50 µl) of saline, C48/80 (2 g/l), endothelin (1 µM), 5-HT (1 mM), chloroquine (4 mM), histamine (89 mM), LPA (4 mM), trypsin (10 U/µl), SLIGRL (2 mM), ß-alanine (224 mM) and BAM8-22 (1 mM). Pruritogens are displayed in order of potency, sorted according to the mean scratch behaviour induced in wild type mice. (l) Grand sum of the scratch behaviour across all pruritogens, n = 4–15, error bars: s.e.m, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (m) Hierarchical cluster analysis of the average scratch behaviour induced by each pruritogen in wild type mice using Ward’s method.