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. 2020 Feb 11;10:2326. doi: 10.1038/s41598-020-59092-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Reduction of histamine- and endothelin-induced scratching through Na_V1.7 and Na_V1.8 inhibition. Scratch behaviour upon intradermal injection of histamine (89 mM) and endothelin (1 µM) following inhibitor treatment relative to control response upon saline injection. (a,b) Pre-treatment with Na_V1.7 inhibitor PF-05089771 (i.p., 90 µg) 3 h prior to acute itch induction. (c,d) Pre-treatment with Na_V1.8 inhibitor A-803467 (i.p., 1.75 mg) 1.5 h before itch assessment. n = 5–12, error bars: s.e.m, *P < 0.05, **P < 0.01.