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. 2020 Feb 11;10:2331. doi: 10.1038/s41598-020-59142-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) A comparative analysis of targets and pathways regulated by unique miRNAs. The bar graph represents the total number of targets and the total number of pathways regulated by unique miRNAs from each cancer types along with the key genes. (B) Regulatory network of unique miRNAs. The Cytoscape network illustrates the interaction of each unique miRNAs specific for each cancer type (represented in yellow). The key genes and pathways, which are common for both unique and common miRNAs, are indicated in cyan and pink. The key genes and pathways that specific for unique miRNAs are indicated in blue and black colours. (C) Heatmap of differentially expressed key genes of unique miRNAs in the various cancer types. The panel shows down-regulated key genes in green and up-regulated key genes in red. Each row represents the key genes whereas each column represents cancer types. The key genes labelled in red are the common key genes between unique and common miRNAs.