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. 2020 Feb 11;10:2362. doi: 10.1038/s41598-020-59276-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Capsular morphotypes differ significantly in mean radius, major axis size, mean pixel intensity, and contrast. Each point represents a single cell, and a small noise was added to each position to avoid overlap. Differences in shape (mean radius) tend to correlate with differences in moments (major axis), but also with texture (contrast). Pixel intensities (basic feature) differed significantly, but effect sizes do not seem to be nearly as large. The types of the features are named as defined in the EBImage R package. Red lines connect the means. Overall and pairwise comparisons computed with Kruskal-Wallis and Wilcoxon tests, respectively. ^*p < = 0.05; ^**p < = 0.01; ^***p < = 0.001; ^****p < = 0.0001.