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. 2020 Feb 11;10:2362. doi: 10.1038/s41598-020-59276-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Capsular morphotypes differ significantly in intensity, shape, moment, and texture. We estimated the expected value (mean) for each cell morphotype across all features using robust regression. The scaled values are represented as color intensities, i.e., the greater the intensity, the greater a given cell type differs from the cross-group average for the corresponding feature. Non-significant regression coefficients were set to zero and in these cases the resulting color corresponds to the baseline (estimate for regular morphotypes). Near-zero values mean the cell morphotype was close to the cross-group average.