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. 2020 Feb 11;11:838. doi: 10.1038/s41467-020-14664-8

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© The Author(s) 2020, corrected publication 2022

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Fig. 4 — a The molar ratio of SOX and HRP was optimized. b The titration curve of sarcosine detection in serum, indicating the ability to detect sarcosine in complicated samples. The dynamic range spans from 50 nM to 10 mM. c Standard variation for a series of sarcosine dilutions for BEH and commercial kit (left). Mean standard variation for sarcosine dilutions for BEH and commercial kit. d Comparison of dynamic range of BEH, commercial kit, and enzyme cascade reaction in solution. The gray area indicates the sarcosine level in serum of healthy people. eThe BEH device was highly specific to sarcosine. The signal from some other interferences such as the isomers of sarcosine (D-alanine and L-alanine) was similar to background signal. Error bars represent the mean ± s.d. of triplicates. Source data are provided as a Source Data file.