Table 3.
The Kinase target networks of CXC chemokines in RCC (LinkedOmics).
| CXC chemokines | Enriched kinase target | Description | Leading EdgeNum | P-value |
|---|---|---|---|---|
| CXCL1 | Kinase_CSNK1D | Casein kinase 1 delta | 5 | 0.020 |
| CXCL2 | Kinase_CSNK1D | Casein kinase 1 delta | 5 | 0.007 |
| Kinase_FER | FER tyrosine kinase | 3 | 0.039 | |
| CXCL3 | Kinase_SGK1 | Serum/glucocorticoid regulated kinase 1 | 1 | 0.037 |
| CXCL5 | Kinase_ATM | ATM serine/threonine kinase | 11 | 0.002 |
| Kinase _MAPK1 | Mitogen-activated protein kinase 1 | 25 | 0.007 | |
| CXCL6 | Kinase_CDK6 | Cyclin dependent kinase 6 | 1 | 0.005 |
| Kinase_PRKAA2 | Protein kinase AMP-activated catalytic subunit alpha 2 | 2 | 0.005 | |
| CXCL7 | Kinase_SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 21 | 0.007 |
| Kinase_MAPK3 | Mitogen-activated protein kinase 3 | 8 | 0.016 | |
| CXCL9 | Kinase_ITK | IL2 inducible T-cell kinase | 2 | 0.003 |
| Kinase_FYN | FYN proto-oncogene, Src family tyrosine kinase | 7 | 0.007 | |
| CXCL10 | Kinase_ITK | IL2 inducible T-cell kinase | 2 | 0.019 |
| Kinase_CSNK1E | Casein kinase 1 epsilon | 4 | 0.020 | |
| CXCL11 | Kinase_LCK | LCK proto-oncogene, Src family tyrosine kinase | 5 | 0.017 |
| Kinase_FYN | FYN proto-oncogene, Src family tyrosine kinase | 7 | 0.012 | |
| CXCL12 | Kinase_SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 21 | 0 |
| Kinase_LYN | LYN proto-oncogene, Src family tyrosine kinase | 6 | 0 | |
| CXCL13 | Kinase_LCK | LCK proto-oncogene, Src family tyrosine kinase | 5 | 0 |
| Kinase_MAPK1 | Mitogen-activated protein kinase 1 | 12 | 0 | |
| CXCL16 | Kinase_LYN | LYN proto-oncogene, Src family tyrosine kinase | 6 | 0 |
| Kinase_FYN | FYN proto-oncogene, Src family tyrosine kinase | 9 | 0 |